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Provides neuroprotection FOXO4-DRI shows potential as a neuroprotective agent by targeting senescent cells that contribute to neuroinflammation and cognitive decline

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NNMT depletes the NAD+ precursor pool by methylating nicotinamide the same nicotinamide that the salvage pathway would otherwise convert back into NAD+ via the enzyme NAMPT

10.1097/00003086-199404000-00046 [DOI] [PubMed] [Google Scholar] Damien C

Pineal gland regulation: The tetrapeptide modulates melatonin synthesis in the pineal gland, potentially restoring age-related declines in melatonin production that contribute to disrupted circadian rhythms and reduced antioxidant defense